Spyder fail to launch

This is my error after launching Spyder, I wonder how to fix it and open Spyder and Jupter, thanks a lot!

C:\ProgramData\Anaconda3\lib\site-packages\paramiko\transport.py:219: CryptographyDeprecationWarning: Blowfish has been deprecated
“class”: algorithms.Blowfish,
Bad file descriptor (C:\ci\zeromq_1616055400030\work\src\epoll.cpp:100)

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I have the same problem